Hydrochloric Acid → HCID 131714324, compound

HRID 1719621Notes

Reaction equation

HRID 1719621 reaction equation
[NH2:1][CH:2]1[CH:9]2[CH:10](O)[C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=3[C:3]1([CH3:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2.[ClH:20].O.Cl.Cl>C(O)C>[OH2:17].[ClH:20].[NH2:1][CH:2]1[C:9]2=[CH:10][C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=3[C:3]1([CH3:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2.[NH2:1][CH:2]1[C:9]2=[CH:10][C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=3[C:3]1([CH3:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2.[ClH:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 13491247HCID 13491247, compoundHCID 21226127Hydrate;dihydrochloride

Product 1

HCID 131714324HCID 131714324, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3,12-diol (0.7 g., 0.002 mole) was dissolved in 20 mL of boiling ethanol. To this solution was added 5 mL ethanol saturated with hydrogen chloride and was allowed to stand overnight. The solvent was evaporated under reduced pressure and the resulting residue was recrystallized from acetone-ethanol (5:1) to afford 400 mg (70% yield) of the title compound as a hydrochloride hemihydrate, mp 216°-218° C.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resulting residue was recrystallized from acetone-ethanol (5:1)

Sources & evidence

ORD record
ord-0eaaf2b0f30142bd89c3f50b397a8c29
Source dataset
uspto-grants-1985_09
Patent number
US04540806

Reaction notes

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