Triethylamine → HCID 5134239, compound

HRID 1719689Notes

Reaction equation

HRID 1719689 reaction equation
[C:1]([O-:8])(=O)/[CH:2]=[CH:3]\C([O-])=O.[N:9]1([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.C(N(CC)CC)C.C1OC2C=CC(C(Cl)=O)=CC=2O1>CN(C)C=O>[C:1]([N:12]1[CH2:13][CH2:14][N:9]([C:15]2[N:16]=[CH:17][CH:18]=[CH:19][N:20]=2)[CH2:10][CH2:11]1)(=[O:8])[CH2:2][CH3:3]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 887471-(2-Pyrimidinyl)piperazineHCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 5288227Maleate(2-)

Product 1

HCID 5134239HCID 5134239, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

5.6 g of acid maleate of 2-(1-piperazinyl)pyrimidine are dissolved in 80 ml of dimethylformamide, then 5.6 ml of triethylamine and 3.8 g of 3,4-methylenedioxy benzoyl chloride are added. The mixture is heated for 12 hours at 130° C. then the solvent is evaporated to dryness in vacuo. The residue is taken up in a dilute solution of hydrochloric acid and washed with ether. The aqueous phase is rendered alkaline by a sodium carbonate solution and extracted with ethyl acetate. The solution is dried over sodium sulfate and the solvent is evaporated to dryness.

Workup

  1. customthe solvent is evaporated to dryness in vacuo
  2. washwashed with ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe solution is dried over sodium sulfate
  5. customthe solvent is evaporated to dryness

Sources & evidence

ORD record
ord-d71ca9acdaee49e6a28842becc6d2348
Source dataset
uspto-grants-1985_09
Patent number
US04542136

Reaction notes

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