反应详情

A mixture of about 9.0 g of 1H-1,2,4-triazole, about 6.24 g of approximately 50% sodium hydride in oil and about 130 ml of dimethylformamide was stirred for about 1.5 hours, then about 33 g of bromobutylphthalimide was added and this mixture was heated on a steam bath for about 6 hours, then concentrated to a solid residue. Water and methylene chloride were added, the organic layer was separated, washed with water, dried and concentrated to a residue. This residue was recrystallized from ethanol, giving about 27.3 g of 2-[4-(1H-1,2,4-triazol-1-yl)butyl]-1H-isoindol-1,3(2H)-dione.

1. temperaturethis mixture was heated on a steam bath for about 6 hours
2. concentrationconcentrated to a solid residue
3. additionWater and methylene chloride were added
4. customthe organic layer was separated
5. washwashed with water
6. customdried
7. concentrationconcentrated to a residue
8. customThis residue was recrystallized from ethanol