反应详情

温度

150 °C

A mixture of 2-amino-5-nitrobenzonitrile (48.9 g), anhydrous potassium carbonate (45.6 g), formamide (240 ml) and N,N-dimethylformamide (200 ml) was stirred for 50 minutes at 150° C. and then cooled to ambient temperature. To the resultant mixture was added a small volume of water with stirring. Precipitated crystals were separated by filtration, washed three times with water and dried under reduced pressure to give crystalline 4-amino-6-nitroquinazoline (50.1 g).

1. temperaturecooled to ambient temperature
2. stirringwith stirring
3. customPrecipitated crystals
4. customwere separated by filtration
5. washwashed three times with water
6. customdried under reduced pressure