Water → 6-Ethylquinazoline-2,4(1H,3H)-dione

HRID 1719921Notes

Reaction equation

HRID 1719921 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[NH:11][C:10](=[O:12])[O:9][C:8](=O)[C:7]=2[CH:14]=1)[CH3:2].[NH2:15]C(N)=O.O>CN(C)C=O>[CH2:1]([C:3]1[CH:14]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:11][C:10](=[O:12])[NH:15][C:8]2=[O:9])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 1176UreaHCID 13060519HCID 13060519, compound

Product 1

HCID 130605146-Ethylquinazoline-2,4(1H,3H)-dioneYield 60.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 6-ethyl-2H-3,1-benzoxazine-2,4(1H)-dione (19.55 g) and urea (6.18 g) in dry N,N-dimethylformamide (98 ml) was heated under reflux for 3 hours and 40 minutes. After the reaction mixture was cooled to ambient temperature, to the mixture was added water with stirring to give crystals, which were separated by filtration, washed with water and dried under reduced pressure to give crystalline 6-ethyl-1H,3H-quinazoline-2,4-dione (11.74 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours and 40 minutes
  3. customto give crystals, which
  4. customwere separated by filtration
  5. washwashed with water
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-ff09c5303b1c41ef88b118e9d9165597
Source dataset
uspto-grants-1985_09
Patent number
US04543356

Reaction notes

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