Benzyl Bromide → HCID 22419805, compound

HRID 1720006Notes

Reaction equation

HRID 1720006 reaction equation
[Cl:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]2[C:5]([NH:6][C:7](=[O:16])[C:8](=[O:15])[N:9]2[OH:14])=[CH:4][CH:3]=1.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C.P([O-])([O-])([O-])=O>[CH2:17]([O:14][N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[C:11]=2[C:12]#[N:13])[NH:6][C:7](=[O:16])[C:8]1=[O:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 2

HCID 7498Benzyl BromideHCID 22419806HCID 22419806, compound

Product 1

HCID 22419805HCID 22419805, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1061PhosphateSolvent

Procedure

To a solution of 2,0 g (~8,4 mmol) 7-chloro-8-cyano-1-hydroxyquinoxaline-2,3(1H,4H)-dione in a mixture of 150 ml ethanol and 175 ml 0,1M phosphate buffer pH 7.4 was added 3.0 g (~17,4 mmol) of benzylbromide. Stirring was continued for 20 h at 24° C. The precipitate was filtered off to give the title compound (2.7 g; 98%), m.p. 227°-229° C.

Workup

  1. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-f59c8ed5064941ebb94b13c0bd8f9c14
Source dataset
uspto-grants-1996_04
Patent number
US05504085

Reaction notes

Loading…