Hydrochloric Acid → HCID 18655292, compound

HRID 1720086Notes

Reaction equation

HRID 1720086 reaction equation
[ClH:1].[CH2:2]([NH:10][C:11](=[O:25])[C@H:12]([C@H:21]([CH2:23][CH3:24])[CH3:22])[NH:13]C(OC(C)(C)C)=O)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CCCCCC>CCOC(C)=O>[ClH:1].[CH2:2]([NH:10][C:11](=[O:25])[C@H:12]([C@H:21]([CH2:23][CH3:24])[CH3:22])[NH2:13])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 10019808HCID 10019808, compound

Product 1

HCID 18655292HCID 18655292, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Hydrogen chloride gas was bubbled into a solution of N-t-butoxycarbonyl-L-isoleucine-phenethylamide (3.1 g, 9.3 mmol) in EtOAc (200 mL) at -20° C. in a dry ice-acetone bath until TLC (EtOAc: hexane, 1:3) indicated complete loss of starting material. The solution was concentrated to dryness to give 2.5 g (100%) of the title compound, which was used without further purification.

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-6d7d47a79c7d4c3ea39825bfc0255958
Source dataset
uspto-grants-1996_04
Patent number
US05504115

Reaction notes

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