HCID 131719370, compound → HCID 131719369, compound

HRID 1720194Notes

Reaction equation

HRID 1720194 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH2:14]1[N:25]([CH2:26][C:27]([OH:29])=[O:28])[CH2:24][CH2:23][N:22]([CH2:30][C:31]([OH:33])=[O:32])[CH2:21][CH2:20][N:19]([CH:34]([C:44]([OH:46])=[O:45])[CH2:35][CH2:36][C:37]2[CH:42]=[CH:41][C:40]([NH2:43])=[CH:39][CH:38]=2)[CH2:18][CH2:17][N:16]([CH2:47][C:48]([OH:50])=[O:49])[CH2:15]1>FC(F)(F)C(O)=O>[NH2:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH2:14]1[N:25]([CH2:26][C:27]([OH:29])=[O:28])[CH2:24][CH2:23][N:22]([CH2:30][C:31]([OH:33])=[O:32])[CH2:21][CH2:20][N:19]([CH:34]([C:44]([OH:46])=[O:45])[CH2:35][CH2:36][C:37]2[CH:38]=[CH:39][C:40]([NH2:43])=[CH:41][CH:42]=2)[CH2:18][CH2:17][N:16]([CH2:47][C:48]([OH:50])=[O:49])[CH2:15]1

Participants

3

Reactant 1

HCID 131719370HCID 131719370, compound

Product 1

HCID 131719369HCID 131719369, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Crude BOC-Ala-PA-DOTA from above was dissolved in trifluoroacetic acid (3.5 mL) and immediately evaporated to dryness under a stream of dry nitrogen. The solid residue was triturated twice with ether (15 mL) and twice with THF (15 mL) to give L-Ala-PA-DOTA (0.066 g: MF (FAB) m/e 617 (positive ion M+Na).

Workup

  1. customimmediately evaporated to dryness under a stream of dry nitrogen
  2. customThe solid residue was triturated twice with ether (15 mL) and twice with THF (15 mL)

Sources & evidence

ORD record
ord-7b805072850a4c0682bdef891b7b797f
Source dataset
uspto-grants-1996_04
Patent number
US05505931

Reaction notes

Loading…