Hydrochloric Acid → Dimoxystrobin

HRID 1720565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1720565
C1(C)C=CC=CC=1.Cl.[CH3:9][C:10]1[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:11]=1[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20](=[N:25][O:26][CH3:27])[C:21]([NH:23][CH3:24])=[O:22]>O>[CH3:9][C:10]1[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:11]=1[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1/[C:20](=[N:25]\[O:26][CH3:27])/[C:21]([NH:23][CH3:24])=[O:22]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 544553462-[(2,5-Dimethylphenoxy)methyl]-alpha-(methoxyimino)-N-methylbenzeneacetamide

Produkt 1

HCID 10936292DimoxystrobinAusbeute 71,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Toluene (3 ml) and conc. hydrochloric acid (0.61 g, 6 mmol) were added to 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-methoxyimino-N-methylacetamide (0.98 g, E/Z=75/25), and the mixture was stirred at 80° C. for 2 hours. After completion of the reaction, water (150 ml) was added. The mixture was extracted with methylene chloride (50 ml) twice, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give crystals (1.01 g, E/Z=95/5). The crystals were recrystallized from toluene to give (E)-2-[2-(2,5-dimethylphenoxymethyl)-phenyl]-2-methoxyimino-N-methylacetamide (0.72 .g, Yield 71.5%) as colorless crystals.

Aufarbeitung

  1. additionwas added
  2. extractionThe mixture was extracted with methylene chloride (50 ml) twice
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customto give crystals (1.01 g, E/Z=95/5)
  6. customThe crystals were recrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-11a589cd0b8241e18b027c1bcba87a0a
Quelldatensatz
uspto-grants-1996_04
Patentnummer
US05506358

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