Trifluoroacetic acid → 6,7-Bis(12-phenyldodecanoyloxy)-4-thiaheptanoic acid

HRID 1720797Notes

Reaction equation

HRID 1720797 reaction equation
C([O:5][C:6](=[O:53])[CH2:7][CH2:8][S:9][CH2:10][CH:11]([O:33][C:34](=[O:52])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)[CH2:12][O:13][C:14](=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:46]1([CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][C:34]([O:33][CH:11]([CH2:12][O:13][C:14](=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:10][S:9][CH2:8][CH2:7][C:6]([OH:53])=[O:5])=[O:52])[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 541161096,7-Bis(12-phenyldodecanoyloxy)-4-thiaheptanoic acid t-butyl ester

Product 1

HCID 224186176,7-Bis(12-phenyldodecanoyloxy)-4-thiaheptanoic acidYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 6,7-bis(12-phenyldodecanoyloxy)-4-thiaheptanoic acid t-butyl ester as obtained in Reference Example 33 (1.22 g) in dichloromethane (2 ml)-trifluoroacetic acid (6 ml) was stirred at room temperature for 2 hours, after which the solvent was distilled off under reduced pressure, to yield the title compound (1.12 g, yield 99%) as a colorless oily substance.

Workup

  1. distillationafter which the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-9ab0196d75684eb892986ef6a42fd4a2
Source dataset
uspto-grants-1996_04
Patent number
US05506267

Reaction notes

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