Hydrochloric Acid → HCID 70094289, compound

HRID 1720861Notes

Reaction equation

HRID 1720861 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[C@H:5]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=1)[NH:6][C:7](=[O:19])[C:8]([NH:11]C(OC(C)(C)C)=O)([CH3:10])[CH3:9])[CH3:2].[ClH:29]>C(OCC)(=O)C.CO>[ClH:29].[CH2:1]([O:3][C:4](=[O:28])[C@H:5]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([OH:27])=[CH:25][CH:26]=1)[NH:6][C:7](=[O:19])[C:8]([NH2:11])([CH3:10])[CH3:9])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10810636N-[2-(t-butoxycarbonylamino)-2-methyl-1-oxopropyl]-L-tyrosine ethyl ester

Product 1

HCID 70094289HCID 70094289, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Into a stirred solution of N-[2-(t-butoxycarbonylamino)-2-methyl-1-oxopropyl]-L-tyrosine ethyl ester (1.46 g, 3.70 mmol) in ethyl acetate (50 mL) and methanol (10 mL) is bubbled hydrochloric acid gas for 10 minutes. The solvent is removed to give N-(2-amino-2-methyl-1-oxopropyl)-L-tyrosine ethyl ester monohydrochloride as a white foam which is used without any further purification.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-e251d246b4a14d508861620eaf3e7df8
Source dataset
uspto-grants-1996_04
Patent number
US05508266

Reaction notes

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