反应详情

The solution of phenethylamine (344 mg, 2.84 mmol) in 20 ml of CH2Cl2 was first treated with the solution of 1,2,3,4-tetrahydro-2-naphthoyl chloride (2.83 mmol) in 2 ml of CH2Cl2 followed by treatment with 10 ml 10% K2CO3 solution. After stirred at r.t. overnight, the organic layer was separated and washed with 2N HCl, water, sat'd brine and dried over Na2SO4. Filtration and removal of solvent gave N-(2-phenylethyl) 1,2,3,4-tetrahydro-2-naphthoic amide as a white powder (793 mg, 100%); mp 86°-87° C.; Calcd for C19H21NO: C 81.67, H 7.59, N 5.01; Found: C 82.00, H 7.27, N 4.77.

1. customthe organic layer was separated
2. washwashed with 2N HCl, water
3. dry with materialdried over Na2SO4
4. filtrationFiltration and removal of solvent