Hydrochloric Acid → HCID 67809084, compound

HRID 1721198Notes

Reaction equation

[Cl:1][C@H:2]1[C@@H:10]2[C@@H:6]([CH2:7][N:8](C(Cl)=O)[CH2:9]2)[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:4][CH2:3]1.Cl>O1CCCC1>[ClH:1].[Cl:1][C@H:2]1[C@@H:10]2[C@@H:6]([CH2:7][NH:8][CH2:9]2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][CH2:3]1

Participants

Conditions

Temperature: 80 °C

Procedure

A solution of 0.4 g of (3aR, 7R,7aR)-7-chloro-2-chlorocarbonyl-4,4-diphenylperhydroisoindole in 6 cm3 of a 1N aqueous solution of hydrochloric acid and 14 cm3 of tetrahydrofuran is heated with stirring at 80° C. for 9 hours. The reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). 0.35 g of (3aR, 7R,7aR)-7-chloro-4,4-diphenylperhydroisoindole hydrochloride is obtained in the form of a white solid.

Workup

concentrationThe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)

Sources & evidence

ORD record: ord-f6b2e8bb4dff4934b0e6cebf0a7c731d
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05508433

Reaction notes

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