反应详情

温度

0 °C

20 g of 3A was dissolved in 100 ml of diglyme and the solution was added dropwise to a vigorously stirred mixture of 2.5 g of sodium hydride and 100 ml of diglyme, under nitrogen at room temperature. The mixture was heated slowly to and held at 150° C. for 6 hours, then cooled, mixed with 200 ml of water and extracted with ether. The extract was dried and stripped of solvent. The residue was distilled in a Kugelrohr apparatus (60° C./0.05 Torr); the resulting residue was dissolved in warm petroleum ether, the solution was chilled to 0° C., and the solid phase was collected and dried, to give ethyl 3-benzisoxazolylcarboxylate (3B), as a white solid, m.p.: 53°-55° C.

1. temperatureThe mixture was heated slowly to and
2. temperaturecooled
3. extractionextracted with ether
4. customThe extract was dried
5. distillationThe residue was distilled in a Kugelrohr apparatus (60° C./0.05 Torr)
6. dissolutionthe resulting residue was dissolved in warm petroleum ether
7. customthe solid phase was collected
8. customdried