Hydrochloric Acid → HCID 13851912, compound

HRID 1721843Notes

Reaction equation

HRID 1721843 reaction equation
[CH2:1]([N:8]([C:12]1[N:20]=[CH:19][N:18]=[C:17]2[C:13]=1[N:14]=[CH:15][N:16]2C1O[C@H](CO)[C@@H](O)[C@H]1O)[CH:9]([CH3:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[CH2:1]([N:8]([C:12]1[N:20]=[CH:19][N:18]=[C:17]2[C:13]=1[NH:14][CH:15]=[N:16]2)[CH:9]([CH3:11])[CH3:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18633806HCID 18633806, compound

Product 1

HCID 13851912HCID 13851912, compoundYield 75%

Procedure

A solution of 3.5 g. (mmol) 6-[N-benzyl-N-(2-propyl)-amino]-9-ribofuranosylpurine and 50 ml. 2N hydrochloric acid is heated under reflux for 30 minutes. After cooling, it is washed with diethyl ether, the aqueous phase is adjusted to pH 7 with aqueous ammonia solution and the precipitate is recrystallized from aqueous propan-2-ol. There is obtained 1.8 g. of the title compound (75% of theory); m.p. 200°-202° C.

Workup

  1. temperatureunder reflux for 30 minutes
  2. temperatureAfter cooling
  3. washit is washed with diethyl ether
  4. customthe precipitate is recrystallized from aqueous propan-2-ol
  5. customThere is obtained 1.8 g

Sources & evidence

ORD record
ord-43fb3e69abfe430db081e126e44de045
Source dataset
uspto-grants-1989_08
Patent number
US04853386

Reaction notes

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