HCID 19860393, compound → HCID 19860376, compound

HRID 1721870Notes

Reaction equation

HRID 1721870 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[C:5]([S:16]([NH:19]C(C)(C)C)(=[O:18])=[O:17])=[CH:4][N:3]=1>FC(F)(F)C(O)=O>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[C:5]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 19860393HCID 19860393, compound

Product 1

HCID 19860376HCID 19860376, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 2-amino-N-(1,1-dimethylethyl)-4-[(3-methylphenyl)amino]-5-pyrimidinesulfonamide (0.90 gm, 0.0027 mol) in trifluoroacetic acid (10 mL) was heated to reflux for 1 hour. After cooling, the solvent was evaporated in vacuo and the resulting solid triturated with ether to give 0.50 g, 67% of product, m.p. 213°-215° C., as a colorless solid.

Workup

  1. temperatureto reflux for 1 hour
  2. temperatureAfter cooling
  3. customthe solvent was evaporated in vacuo
  4. customthe resulting solid triturated with ether

Sources & evidence

ORD record
ord-cb258a03095f451d91326dcbf05aca1e
Source dataset
uspto-grants-1989_08
Patent number
US04853389

Reaction notes

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