Potassium Carbonate → Ethyl-2-(2-propylimidazol-1-yl)propanoate

HRID 1721885Notes

Reaction equation

HRID 1721885 reaction equation
[CH2:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)[CH2:2][CH3:3].Br[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:1][CH2:2][CH3:3])[CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 1626172-Propylimidazole

Product 1

HCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Propylimidazole (5.5 g), ethyl 2-bromopropionate (9.95 g) and potassium carbonate (12.4 g) were stirred in refluxing acetonitrile (100 ml) for 72 hours. The suspension was allowed to cool, filtered and the solvent removed under reduced pressure, yielding the title compound as an off-white foam, 9.2 g [88%].

Workup

  1. temperatureto cool
  2. filtrationfiltered
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-2bd3e86144384b45b2db53708bb5d401
Source dataset
uspto-grants-1989_08
Patent number
US04853392

Reaction notes

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