反应详情

温度

120 °C

A mixture of 6.5 g of the product of Step A in 30 ml of tert.-butylamine was heated at 120° C. for 30 hours and was then diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried over a deshydrant, filtered and evaporated to dryness. The residue was chromatographed over silica and eluted with a 9-1 ethyl acetate-triethylamine mixture to obtain 7.264 g of 1-[4-{-2-(1,1-dimethylethylamino)-ethoxy}-phenyl]-ethanone.

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with water
3. customdried over a deshydrant
4. filtrationfiltered
5. customevaporated to dryness
6. customThe residue was chromatographed over silica
7. washeluted with a 9-1 ethyl acetate-triethylamine mixture