Glycidol → HCID 13798875, compound

HRID 1721990Notes

Reaction equation

HRID 1721990 reaction equation
[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[CH2:6]([O:8][CH2:9][CH2:10][NH2:11])[CH3:7]>C(O)(C)C>[CH2:6]([O:8][CH2:9][CH2:10][NH:11][CH2:1][CH:2]([OH:3])[CH2:4][OH:5])[CH3:7]

Participants

4

Reactant 2

HCID 11164GlycidolHCID 66970Ethoxyethylamine

Product 1

HCID 13798875HCID 13798875, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution of glycidol (15 g, 0.2 mol) in isopropanol (50 ml) was added dropwise under N2 at 70° C. to a solution of 2-ethoxyethylamine (53 g, 0.6 mol) in isopropanol (125 ml). After 15 hours, the isopropanol was removed under reduced pressure (20 mm) and the residue distilled at 120°-5° C. at 0.4 mm to yield 22.6 g (69%) of 1.

Workup

  1. customthe isopropanol was removed under reduced pressure (20 mm)
  2. distillationthe residue distilled at 120°-5° C. at 0.4 mm

Sources & evidence

ORD record
ord-639f0ec039274968a09b646d3ce8405e
Source dataset
uspto-grants-1989_08
Patent number
US04853383

Reaction notes

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