Hydrochloric Acid → HCID 178488962, compound

HRID 1722014Notes

Reaction equation

HRID 1722014 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)=[CH:5][CH:4]=1.[ClH:18]>O>[Cl:18][C:8]1[CH:7]=[C:6]([C:9]2[NH:10][CH:11]=[C:12]([C:14]([F:17])([F:15])[F:16])[N:13]=2)[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178488961HCID 178488961, compound

Product 1

HCID 178488962HCID 178488962, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a mixture of 7 (7.9 g, 0.033 mol), H2O (60 ml) and concentrated HCl (150 ml) stirred at room temperature was added dropwise a solution of KC103 (1.5 g, 0.012 mol) in H2O (65 ml). After 4 1/2 hours, the suspension was filtered and the solid washed with H2O and dried in vacuo to yield 8.1 g (89%) of 55, m.p. 208-210.

Workup

  1. filtrationAfter 4 1/2 hours, the suspension was filtered
  2. washthe solid washed with H2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-2f5f8d6ba8b641fb9793ab71fbd05b1e
Source dataset
uspto-grants-1989_08
Patent number
US04853383

Reaction notes

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