Triethylamine → HCID 23049304, compound

HRID 1722225Notes

Reaction equation

HRID 1722225 reaction equation
[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([OH:15])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][NH2:29]>CCOCC>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][NH:29][C:13](=[O:15])/[CH:12]=[CH:11]/[CH2:10][CH2:9][C:8]#[C:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 211563-MethoxybenzylamineHCID 23049308HCID 23049308, compound

Product 1

HCID 23049304HCID 23049304, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

7-phenylhept-2E-en-6-ynoic acid (100 mg) was converted to the acid chloride as described in Example 2(a). The acid chloride was treated with triethylamine (73 ul) and 3-methoxybenzylamine (77 ul) in ether (2 ml). The product was recovered as described in Example 1 and purified by chromatography on silica, eluting with ether:hexane (1:1) to yield N-(3-methoxybenzyl)-7-phenylhept-2E-en-6-ynamide as a colourless solid, m.p. 96.3°-98.9°.

Workup

  1. customThe product was recovered
  2. custompurified by chromatography on silica
  3. washeluting with ether:hexane (1:1)

Sources & evidence

ORD record
ord-368d86f884c4499596a9945c43551f04
Source dataset
uspto-grants-1989_08
Patent number
US04855086

Reaction notes

Loading…