Isopropanol → HCID 13799210, compound

HRID 1722258Notes

Reaction equation

HRID 1722258 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH2:12][CH2:13][CH2:14][C:15](=[O:22])[C:16]=3[C:17]=2[C:18]=1[CH2:19][O:20][CH3:21])=[O:5])[CH3:2].[CH:23](O)(C)C>CC([O-])C.CC([O-])C.CC([O-])C.CC([O-])C.[Ti+4]>[CH:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH2:12][CH2:13][CH2:14][C:15](=[O:22])[C:16]=3[C:17]=2[C:18]=1[CH2:19][O:20][CH3:21])=[O:5])([CH3:23])[CH3:2]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 13799208HCID 13799208, compound

Product 1

HCID 13799210HCID 13799210, compound

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideCatalyst

Procedure

0.2 g of 4-methoxymethyl-5-oxo-5,6,7,8-tetrahydro-betacarboline-3-carboxylic acid ethyl ester is refluxed in 10 ml of isopropanol with 0.1 ml of titanium tetraisopropylate for 1.5 hours under argon atmosphere. The crystals precipitated after cooling are sectioned off and rewashed with isopropanol. 0.135 g of 4-methoxymethyl-5-oxo-5,6,7,8 -tetrahydro-beta-carboline-3-carboxylic acid isopropyl ester with a melting point of 243°-245° C. is obtained.

Workup

  1. customThe crystals precipitated
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-ed38586caba34db98bb9a1993a427f69
Source dataset
uspto-grants-1989_08
Patent number
US04855295

Reaction notes

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