HCID 14673794, compound → HCID 14673796, compound

HRID 1722318Notes

Reaction equation

HRID 1722318 reaction equation
[CH3:1][O:2][CH:3]1[CH:8]([O:9][CH3:10])[CH2:7][CH:6]([N:11](C)[CH2:12]C2C=CC=CC=2)[CH:5]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:4]1>C(O)C.[OH-].[OH-].[Pd+2]>[CH3:12][NH:11][CH:6]1[CH2:7][CH:8]([O:9][CH3:10])[CH:3]([O:2][CH3:1])[CH2:4][CH:5]1[N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 1

HCID 14673794HCID 14673794, compound

Product 1

HCID 14673796HCID 14673796, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

The N-benzylated amine from Step 5 (2.7 mmol) was dissolved in 30 mL of ethanol and treated with 1 mass equivalent of palladium hydroxide on carbon. This mixture was placed under an atmosphere of hydrogen gas, initially at 50 psi (445 kPa) for 12 hours.

Sources & evidence

ORD record
ord-8ac3f96fd44845e99e2151dc1ceb5f96
Source dataset
uspto-grants-1989_08
Patent number
US04855316

Reaction notes

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