Potassium Carbonate → HCID 178525644, compound

To a mixture of 1.5 g of 2,5-dimercapto-1,3,4-thiadiazole, 1.3 g of anhydrous potassium carbonate, and 20 ml of N,N-dimethylformamide was added 1.6 g of 3-bromopropionic acid, whereby the red color of the reaction mixture began to gradually fade and the reaction mixture became yellow. Then, the reaction mixture was poured into 100 ml of ice water and extracted with 30 ml of ethyl acetate three times. The extract thus obtained was washed with water and extracted with 20 ml of an aqueous solution of 5% sodium hydrogen carbonate two times. The extract was washed with ethyl acetate, acidified with diluted hydrochloric acid, and extracted with 30 ml of ethyl acetate three times and the extract thus obtained was washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to provide 0.76 g of 3-[(5-mercapto-1,3,4-thiadiazol-2-yl)thio]propionic acid.

1. extractionextracted with 30 ml of ethyl acetate three times
2. extractionThe extract thus
3. customobtained
4. washwas washed with water
5. extractionextracted with 20 ml of an aqueous solution of 5% sodium hydrogen carbonate two times
6. washThe extract was washed with ethyl acetate
7. extractionextracted with 30 ml of ethyl acetate three times
8. extractionthe extract thus
9. customobtained
10. washwas washed with water
11. dry with materialdried over anhydrous sodium sulfate
12. concentrationconcentrated under reduced pressure

ORD record

ord-d3bfbbea58c34e069872f2a0f19b3d0c

Source dataset

uspto-grants-1989_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04855310