1-Tetralone → HCID 19595604, compound

HRID 1722637Notes

Reaction equation

HRID 1722637 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH2:12]1[CH2:22][C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[O:21]1[C:20]2[CH:22]=[CH:12][CH:13]=[CH:14][C:19]=2[CH:18]=[CH:17][CH2:16][C:15]1=[O:9]

Participants

5

Reactant 3

HCID 107241-TetraloneHCID 70297m-Chloroperbenzoic acidHCID 516892Sodium Bicarbonate

Product 1

HCID 19595604HCID 19595604, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To 100 g of m-chloroperbenzoic acid in 1 l of chloroform at 0° C. is added dropwise 100 g of α-tetralone in 250 ml chloroform. After 5 days of stirring at room temperature the reaction mixture is treated carefully with 1 l sat. NaHCO3 and stirred for 1/2 hour. The organic layer is separated, washed with 500 ml of water and solid NaHCO3 until no evolution of gas. The organic layer is separated washed with sat. NaHCO3 and water and dried (MgSO4). After filtering and concentrating to dryness it is vaccum distilled to obtain low melting material which is used directly in the next step.

Workup

  1. stirringstirred for 1/2 hour
  2. customThe organic layer is separated
  3. washwashed with 500 ml of water and solid NaHCO3 until no evolution of gas
  4. customThe organic layer is separated
  5. washwashed with sat. NaHCO3 and water
  6. dry with materialdried (MgSO4)
  7. filtrationAfter filtering
  8. concentrationconcentrating to dryness it
  9. distillationis vaccum distilled
  10. customto obtain low melting material which

Sources & evidence

ORD record
ord-7ba70d6c80a5421c97e1c3aebd93d580
Source dataset
uspto-grants-1989_08
Patent number
US04857517

Reaction notes

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