Phenol → HCID 18634375, compound

HRID 1722665Notes

Reaction equation

C(S)[CH2:2][C:3]1[CH:8]=CC=C[CH:4]=1.[C:10]1([OH:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH2:17]1C[O:20][CH2:19][CH2:18]1.C[N:23]([CH:25]=[O:26])[CH3:24]>>[CH2:8]([C@H:24]1[C@H:19]([CH2:18][CH2:17][O:16][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:20][C:25](=[O:26])[NH:23]1)[CH:3]([CH3:2])[CH3:4]

Participants

Reactant 4

HCID 996Phenol

HCID 6228Dimethylformamide

HCID 8028Tetrahydrofuran

HCID 781262-Phenylethanethiol

Product 1

HCID 18634375HCID 18634375, compoundYield 54%

Procedure

Using the procedure of example 4 but changing phenethyl mercaptan to phenol and THF to DMF gave the desired compound in 54% yield. Mass spectrum: M+ =264.

Sources & evidence

ORD record: ord-dd8cf3fffdeb413589c822d98cea22a9
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04857507

Reaction notes

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