1,1-Dimethylhydrazine → HCID 136126108, compound

HRID 1722699Notes

Reaction equation

HRID 1722699 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[N:21]=[C:20]([NH2:25])[NH:19][C:18]3=[O:26])[CH2:11][C:12]#[CH:13])=[CH:6][CH:5]=1)(=O)[CH3:2].[CH3:27][N:28]([CH3:30])[NH2:29]>CO>[NH2:25][C:20]1[NH:19][C:18](=[O:26])[C:17]2[C:22](=[CH:23][CH:24]=[C:15]([CH2:14][N:10]([C:7]3[CH:6]=[CH:5][C:4]([C:1](=[N:29][N:28]([CH3:30])[CH3:27])[CH3:2])=[CH:9][CH:8]=3)[CH2:11][C:12]#[CH:13])[CH:16]=2)[N:21]=1

Participants

4

Reactant 2

HCID 59761,1-DimethylhydrazineHCID 135855765HCID 135855765, compound

Product 1

HCID 136126108HCID 136126108, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3.46 g (10 mmol) of 6-[[(4-acetylphenyl)-2-propynylamino]methyl]-2-amino-4(3H)-quinazolinone (see Example 2j) and 6.01 g (100 mmol) of 1,1-dimethylhydrazine in 250 ml of methanol is heated under reflux for eighteen hours. The solution is concentrated and the residue recrystallized from methanol to give the product.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for eighteen hours
  3. concentrationThe solution is concentrated
  4. customthe residue recrystallized from methanol
  5. customto give the product

Sources & evidence

ORD record
ord-8cf845303bbc44caa2ab42a2827d1f38
Source dataset
uspto-grants-1989_08
Patent number
US04857530

Reaction notes

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