反应详情

A mixture of 2-propionylthiophene (50 g), sodium cyanide (19.9 g), ammonium bicarbonate (106 g) and an aqueous methanol solution is stirred for 5 hours under increased pressure with heating. After cooling, the precipitates are collected by filtration, washed and dried, whereby 5-ethyl-5-(2-thienyl)hydantoin (45 g) is obtained.

1. temperatureunder increased pressure
2. temperaturewith heating
3. temperatureAfter cooling
4. filtrationthe precipitates are collected by filtration
5. washwashed
6. customdried