Methanol → HCID 14650083, compound

HRID 1722740Notes

Reaction equation

HRID 1722740 reaction equation
[C:1]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)(=O)[CH2:2][CH3:3].[C-:10]#[N:11].[Na+].[C:13](=[O:16])(O)[O-].[NH4+:17].C[OH:19]>>[CH2:2]([C:1]1([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[NH:17][C:10](=[O:19])[NH:11][C:13]1=[O:16])[CH3:3]

Participants

5

Reactant 4

HCID 887MethanolHCID 8929Sodium CyanideHCID 14013Ammonium BicarbonateHCID 261792-Propionylthiophene

Product 1

HCID 14650083HCID 14650083, compound

Procedure

A mixture of 2-propionylthiophene (50 g), sodium cyanide (19.9 g), ammonium bicarbonate (106 g) and an aqueous methanol solution is stirred for 5 hours under increased pressure with heating. After cooling, the precipitates are collected by filtration, washed and dried, whereby 5-ethyl-5-(2-thienyl)hydantoin (45 g) is obtained.

Workup

  1. temperatureunder increased pressure
  2. temperaturewith heating
  3. temperatureAfter cooling
  4. filtrationthe precipitates are collected by filtration
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-74becec1bfa84b4e9bd0d9ac4bb470fc
Source dataset
uspto-grants-1989_08
Patent number
US04857543

Reaction notes

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