Hydrochloric Acid → HCID 136084769, compound

HRID 1722751Notes

Reaction equation

HRID 1722751 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][C:11]([CH3:15])=[C:12]([CH3:14])[N:13]=2)=[CH:5][CH:4]=1.Cl.[OH-].[NH4+]>N1C=CC=CC=1>[CH3:14][C:12]1[N:13]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[S:10][C:11]=1[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 54280119HCID 54280119, compound

Product 1

HCID 136084769HCID 136084769, compoundYield 58.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product of part (a) (70.7 g) was added to 470 g pyridine saturated with hydrogen chloride gas, and the mixture was heated 2 hours at reflux. The reaction mixture was poured into 3000 ml ice-water, made basic with ammonium hydroxide, and the solid product was collected. The latter was purified by recrystallization from toluene to give 38.8 g 4-(4,5-dimethyl-2-thiazolyl)phenol, m.p. 194-195° C.

Workup

  1. temperaturethe mixture was heated 2 hours
  2. temperatureat reflux
  3. customthe solid product was collected
  4. customThe latter was purified by recrystallization from toluene

Sources & evidence

ORD record
ord-849a669f4275470fbf1c250ed75895fc
Source dataset
uspto-grants-1989_08
Patent number
US04857539

Reaction notes

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