Hydrochloric Acid → HCID 14989148, compound

HRID 1722794Notes

Reaction equation

HRID 1722794 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[OH:16])([CH3:4])[CH3:3].C(N(CC)CC)C.[CH3:24][C:25]([CH:27]=[CH2:28])=[O:26].Cl>CO>[CH3:4][C:2]([C:5]1[CH:10]=[C:9]([S:11][CH2:28][CH2:27][C:25](=[O:26])[CH3:24])[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[OH:16])([CH3:1])[CH3:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6570Methyl vinyl ketoneHCID 8471TriethylamineHCID 703702,6-Di-tert-butyl-4-mercaptophenol

Product 1

HCID 14989148HCID 14989148, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound of Example 2 (2.0 g) was dissolved in methanol (20 ml) and triethylamine (0.5 ml) added followed by methylvinylketone (0.0084 mole). The reaction was stirred under nitrogen for about 20 hours. 0.1N Hydrochloric acid (80 ml) was added and the aqueous phase extracted with ethyl ether. The organic extracts were dried over sodium sulfate, filtered, the solvent removed in vacuo and the residue chromatographed on silica to give the title compound, m.p. ca. 79°-81° C. Analysis calc. for C18 308 H28O2S(48): Calc.: C, 70.09; H, 9.15; S, 10.39. Found: C, 70.15; H, 9.00; S, 10.53.

Workup

  1. extractionthe aqueous phase extracted with ethyl ether
  2. dry with materialThe organic extracts were dried over sodium sulfate
  3. filtrationfiltered
  4. customthe solvent removed in vacuo
  5. customthe residue chromatographed on silica

Sources & evidence

ORD record
ord-3cd6e9a9b0a347cc9d86a4625d5bcae8
Source dataset
uspto-grants-1989_08
Patent number
US04857558

Reaction notes

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