反应详情

Hydrogen chloride was passed into a solution of 4 g of (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 50 ml of isopropyl alcohol with stirring under ice-cooling, and 100 ml of dry benzene was added to the mixture. The mixture was heated under reflux for 10 minutes while removing water formed during the reaction using a molecular sieve. The reaction mixture was concentrated under reduced pressure obtain 5.7 g of isopropyl (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride as a white powder.

1. temperaturecooling
2. temperatureThe mixture was heated
3. temperatureunder reflux for 10 minutes
4. customwhile removing water
5. customformed during the reaction
6. concentrationThe reaction mixture was concentrated under reduced pressure