Triethylamine → HCID 14255272, compound

HRID 1722925Notes

Reaction equation

HRID 1722925 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7]([N:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])[CH3:11])(=[O:9])=[O:8])[N:3]=1.[CH3:20][N:21]=[C:22]=[O:23].C(N(CC)CC)C>O1CCCC1>[NH2:1][C:2]1[N:6]([C:22](=[O:23])[NH:21][CH3:20])[N:5]=[C:4]([S:7]([N:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])[CH3:11])(=[O:9])=[O:8])[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 178482231HCID 178482231, compound

Product 1

HCID 14255272HCID 14255272, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.0 g (6.2 mmol) 5-Amino-N-(2,6-dichlorophenyl)-N-methyl-1,2,4-triazole-3-sulphonamide was suspended in 30 ml tetrahydrofuran and treated with 0.5 ml (8.5 mmol) methyl isocyanate and 0.9 ml (6.5 mmol) triethylamine. The mixture was stirred for 3 hours at room temperature and allowed to stand overnight. The solution was concentrated and the residue chromatographed on silica gel using a mixture of hexane and ethyl acetate.

Workup

  1. waitto stand overnight
  2. concentrationThe solution was concentrated
  3. customthe residue chromatographed on silica gel using
  4. additiona mixture of hexane and ethyl acetate

Sources & evidence

ORD record
ord-99d70045259d4cad92f7e4ed68cfb29c
Source dataset
uspto-grants-1989_08
Patent number
US04859231

Reaction notes

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