Dimethyl Sulfate → HCID 20026051, compound

HRID 1722948Notes

Reaction equation

HRID 1722948 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[NH:14][C:13]2=[O:27])=[C:4]([F:28])[CH:3]=1.[C:29](=O)(O)[O-].[Na+].S(OC)(OC)(=O)=O>CC(C)=O>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:25])([F:26])[C:21]([F:24])([F:23])[F:22])[N:14]([CH3:29])[C:13]2=[O:27])=[C:4]([F:28])[CH:3]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 516892Sodium BicarbonateHCID 20026095HCID 20026095, compound

Product 1

HCID 20026051HCID 20026051, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione in acetone with sodium bicarbonate and dimethyl sulphate there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-1-methyl-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione, m.p. 107°-109° C.;

Sources & evidence

ORD record
ord-b6147a10054048c889e5316bdd96c8d4
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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