Sodium Carbonate → HCID 20026075, compound

HRID 1722965Notes

Reaction equation

HRID 1722965 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1.[C:23]1([CH2:29][CH2:30][CH2:31]Br)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[Cl:1][C:2]1[C:7]([O:8][CH2:31][CH2:30][CH2:29][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 12503(3-Bromopropyl)benzeneHCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 20026075HCID 20026075, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with 3-phenylpropyl bromide and sodium carbonate in dimethylformamide there is obtained 3-[4-chloro-2-fluoro-5-(3-phenylpropoxy)-phenyl]-1-methyl-6 -trifluoromethyl-2,4(1H,3H)-pyrimidinedione, 1H-NMR (CDCl3, 400 MHZ): 7.15°-7.34 ppm (m,6H), 6.71 ppm (d,1H), 6.36 ppm (s,1H), 3.96 ppm (t,2H), 3.55 ppm (d,3H), 2.83 ppm (t,2H), 2.10°-2.20 ppm (m,2H):

Sources & evidence

ORD record
ord-c45bd0ba9f424d23af72b7f4db9781fd
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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