Triethylamine → HCID 70394916, compound

HRID 1722971Notes

Reaction equation

HRID 1722971 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1.[CH:23]1([CH2:29][N:30]=[C:31]=[O:32])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.C(N(CC)CC)C>C(Cl)Cl>[CH:23]1([CH2:29][NH:30][C:31](=[O:32])[O:8][C:7]2[CH:6]=[C:5]([N:9]3[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]([CH3:20])[C:10]3=[O:21])[C:4]([F:22])=[CH:3][C:2]=2[Cl:1])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 3414518(Isocyanatomethyl)cyclohexaneHCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 70394916HCID 70394916, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with cyclohexylmethyl isocyanate and triethylamine in methylene chloride there is obtained 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidinyl]-4-fluorophenyl cyclohexylmethylcarbamate, m.p. 132°-135° C.;

Sources & evidence

ORD record
ord-83e296648cdb487697e93da258625301
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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