Sodium ion → 4-[(4-Bromo-phenyl)-(6-fluoro-pyridin-2-yloxy)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 172304Notes

Reaction equation

HRID 172304 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]([OH:15])[c:16]2[cH:17][cH:18][c:19]([Br:22])[cH:20][cH:21]2)[CH2:12][CH2:13]1.[F:25][c:26]1[n:27][c:28]([F:32])[cH:29][cH:30][cH:31]1.[H-:24].[Na+:23].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]([O:15][c:28]2[n:27][c:26]([F:25])[cH:31][cH:30][cH:29]2)[c:16]2[cH:17][cH:18][c:19]([Br:22])[cH:20][cH:21]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 739342,6-DifluoropyridineHCID 166653HydrideHCID 57603260Tert-butyl 4-((4-bromophenyl)(hydroxy)methyl)piperidine-1-carboxylate

Product 1

HCID 689728724-[(4-Bromo-phenyl)-(6-fluoro-pyridin-2-yloxy)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-7f7c50984c044d19b0c4d812306ca41c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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