Ethanol → HCID 20026754, compound

HRID 1723163Notes

Reaction equation

HRID 1723163 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[C:5]([CH3:14])[C:6]=1C(OC(C)(C)C)=O.C(O)C>Cl>[ClH:21].[NH2:1][C:2]1[S:3][C:4]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[C:5]([CH3:14])[CH:6]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 20026735HCID 20026735, compound

Product 1

HCID 20026754HCID 20026754, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The above thiophene (2.0 g) in 10 ml of 6M HCl is heated at 80° for 33 hours. Ethanol is added, and the solvent and water are then removed. Ether is added to the residue, the suspension is filtered and the final solid is rinsed with ether to give 2-amino-4-methyl-5-(4-chlorophenyl)thiophene hydrochloric acid salt.

Workup

  1. customthe solvent and water are then removed
  2. additionEther is added to the residue
  3. filtrationthe suspension is filtered
  4. washthe final solid is rinsed with ether

Sources & evidence

ORD record
ord-02f24a18563c4bd9bf413aace7aa776d
Source dataset
uspto-grants-1989_08
Patent number
US04859699

Reaction notes

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