Hydrochloric Acid → HCID 20026743, compound

HRID 1723165Notes

Reaction equation

HRID 1723165 reaction equation
Cl.[SH2:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[CH2:11][CH2:12][C:13]#[N:14])=[CH:6][CH:5]=1>CO>[ClH:3].[NH2:14][C:13]1[S:2][C:10]([C:7]2[CH:8]=[CH:9][C:4]([Cl:3])=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 402Hydrogen SulfideHCID 5873524-(4-Chlorophenyl)-4-oxobutanenitrile

Product 1

HCID 20026743HCID 20026743, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl and H2S gas are bubbled through a solution of the above nitrile (7.70 g, 40.0 mmol) in 100 ml of methanol at 10°-20° for 7 hours. The suspension is then stirred at RT overnight. It is dried, filtered, washed with ether and dried with suction under an N2 atmosphere to give 2-amino-5-(4-chlorophenyl)thiophene hydrochloric acid salt, a slightly purplish powder.

Workup

  1. customIt is dried
  2. filtrationfiltered
  3. washwashed with ether
  4. customdried with suction under an N2 atmosphere

Sources & evidence

ORD record
ord-635ba454883b498fbe2ee6a32cb8e999
Source dataset
uspto-grants-1989_08
Patent number
US04859699

Reaction notes

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