Hydrochloric Acid → HCID 20026736, compound

HRID 1723169Notes

Reaction equation

HRID 1723169 reaction equation
[N+:1]([C:4]1[S:5][C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[C:7]([Cl:9])[CH:8]=1)([O-])=O.C(OC(=O)C)(=O)C.Cl.CO>C(O)(=O)C.[Fe]>[ClH:9].[NH2:1][C:4]1[S:5][C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[C:7]([Cl:9])[CH:8]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 7918Acetic AnhydrideHCID 20026742HCID 20026742, compound

Product 1

HCID 20026736HCID 20026736, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Following the procedure of Example 12, 2-nitro-4-chloro-5-(4-chlorophenyl)thiophene (2.3 g) is reacted with acetic anhydride (14 ml) and iron powder (2.3 g) in acetic acid (14 ml), followed by reacton with HCl and methanol (30 ml) to give 2-amino-4-chloro-5-(4-chlorophenyl)thiophene hydrochloric acid salt.

Sources & evidence

ORD record
ord-7b5044c88e3f4bcfa6abc85a84cc9874
Source dataset
uspto-grants-1989_08
Patent number
US04859699

Reaction notes

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