反应详情

A mixture of sodium hydride (0.05 g; 0.01 mol; 50% suspension in mineral oil); 2,3-dihydrophthalazine-1,4-dione (1.6 g; 0.01 mol); and ethylbromoacetate (excess) in anhydrous dimethylformamide (50 ml) was refluxed for 24 hours. The dimethylformamide solvent was then evaporated affording a gummy material. This gummy material was purified over column silica gel using chloroform: ethyl acetate (1:1) to obtain the product, 2-(1'-carbethoxymethyl)-2,3-dihydrophthalazine-1,4-dione.

1. customThe dimethylformamide solvent was then evaporated
2. customaffording a gummy material
3. customThis gummy material was purified over column silica gel