Hydrochloric Acid → HCID 18435654, compound

HRID 1723515Notes

Reaction equation

HRID 1723515 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[NH:24]1[CH:28]=[CH:27][N:26]=[CH:25]1.Cl>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2/[CH:13]=[CH:14]/[C:15]2[O:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:28]=[CH:27][N:26]=[CH:25]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 18435640HCID 18435640, compound

Product 1

HCID 18435654HCID 18435654, compoundYield 40%

Procedure

The title compound was prepared in accordance with Example 18 starting with (D) of Example 18 (2.5 g, 7.6 mmol) and using imidazole in place of dibutylamine to produce 1.1 g (40% yield) of the title compound as the HCl salt, mp 204°-205° C. IR(KBr): 3400, 1600 cm-1. MS: 360(MH+). 1H NMR (CD3OD): δ 9.02 (s, 1H), 7.89-6.89 (m, 12H), 4.38 (t, J=5.3 Hz, 2H), 4.08 (t, J=5.4 Hz, 2H), 1.97 (m, 4H).

Sources & evidence

ORD record
ord-c910b1d890604bbfa716932b602d8a7b
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

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