Hydrochloric Acid → HCID 14146384, compound

HRID 1723519Notes

Reaction equation

HRID 1723519 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]2[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)=[CH:8][CH:7]=1.[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1.Cl>>[N:23]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]3[S:15][C:16]4[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 14146365HCID 14146365, compound

Product 1

HCID 14146384HCID 14146384, compoundYield 39%

Procedure

The title compound was prepared in accordance with Example 28 starting with (F) of Example 28 (5.0 g, 15 mmol) and using imidazole in place of dibutylamine to produce 2.4 g (39% yield) of the title compound as the HCl salt, mp 231°-232° C. IR(KBr): 1595 cm-1. MS: 362(MH+). 1H NMR (CD3OH): δ 9.01 (s, 1H), 7.99-6.91 (m, 12H), 4.21 (t, J=5.2 Hz, 2H), 4.03 (t, J=5.3 Hz, 2H), 2.32 (m, 2H).

Sources & evidence

ORD record
ord-a16b2beaf13d44ea9bda54780ff378f7
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

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