Hydrochloric Acid → HCID 10133649, compound

HRID 1723530Notes

Reaction equation

HRID 1723530 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][CH:7]=1.[CH2:21]([NH:24][CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23].Cl>>[CH2:21]([N:24]([CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][CH:7]=1)[CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8902DipropylamineHCID 14146396HCID 14146396, compound

Product 1

HCID 10133649HCID 10133649, compoundYield 19%

Procedure

The title compound was prepared as described in Example 43 starting with (I) of Example 43 (2.0 g, 6.3 mmol) and using dipropylamine in place of dibutylamine to produce 0.41 g (19% yield) of the title compound as the HCl salt, mp 142°-143° C. IR(KBr): 3400, 1600 cm-1. MS: 369(MH+). 1H NMR (CDCl3): δ 8.19-6.95 (m, 8H), 4.19 (t, J=5.1 Hz, 2H), 3.01 (m, 6H), 2.64-0.82 (m, 12H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-02dffdd7c06e4f6e9e30eccb72326465
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

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