Methyl iodide → Hydrogen iodide

HRID 1723626Notes

Reaction equation

HRID 1723626 reaction equation
[CH3:1][I:2].[CH2:3]([O:10][C:11](=[O:25])[NH:12][CH:13]1[CH2:18][CH2:17][CH:16]([N:19]([CH3:24])[C:20]([NH:22][CH3:23])=[S:21])[CH2:15][CH2:14]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(C#N)(C)=O>[CH2:3]([O:10][C:11](=[O:25])[NH:12][CH:13]1[CH2:14][CH2:15][CH:16]([N:19]([CH3:24])[C:20](=[N:22][CH3:23])[S:21][CH3:1])[CH2:17][CH2:18]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[IH:2]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 87643180[4-(1,3-Dimethyl-thioureido)-cyclohexyl]carbamic acid benzylester

Product 2

HCID 24841Hydrogen iodideHCID 68981797HCID 68981797, compound

Reagents, catalysts & solvents 1

HCID 694302-OxopropiononitrileSolvent

Procedure

0.18 ml of methyliodide are added to a solution of 0.64 g [4-(1,3-dimethyl-thioureido)-cyclohexyl]carbamic acid benzylester in 30 ml of AcCN. The mixture obtained is refluxed for 2.5 hours and solvent is evaporated. [4-(1,2,3-Trimethyl-isothioureido)-cyclohexyl]-carbamic acid benzylester in the form of a hydroiodide is obtained.

Workup

  1. customThe mixture obtained
  2. temperatureis refluxed for 2.5 hours
  3. customsolvent is evaporated

Sources & evidence

ORD record
ord-dfa80a1a88114ecb8b1374df58ae837b
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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