Hydrochloric Acid → Hydrochloric Acid

HRID 1723628Notes

Reaction equation

HRID 1723628 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]([CH3:12])[C:9]([NH2:11])=[S:10])[CH2:4][CH2:3]1.[ClH:13].[CH3:14][I:15]>CO>[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]([CH3:12])[C:9](=[NH:11])[S:10][CH3:14])[CH2:4][CH2:3]1.[ClH:13].[IH:15]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 178485203HCID 178485203, compound

Product 3

HCID 313Hydrochloric AcidHCID 24841Hydrogen iodideHCID 178504041HCID 178504041, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.6 g of 1-(trans-4-aminocyclohexyl)-1-methyl-thiourea in the form of a hydrochloride in 30 ml of MeOH and 0.22 ml of methyliodide is refluxed for 2 hours, solvent is evaporated and 1-(trans-4-aminocyclohexyl)-1,2-dimethyl-isothiourea in the form of a hydrochloride and a hydroiodide is obtained.

Workup

  1. temperatureis refluxed for 2 hours
  2. customsolvent is evaporated

Sources & evidence

ORD record
ord-358755067df943e3b6940451c3eff180
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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