Hydrochloric Acid → HCID 68529741, compound

HRID 1723850Notes

Reaction equation

HRID 1723850 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[F:24])[N:17]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[F:31])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>O1CCOCC1.CCOC(C)=O>[ClH:32].[F:24][C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[C:15]([O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[N:16][N:17]2[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 685328364-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 68529741HCID 68529741, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

The title product was prepared as described above for Example 41 using (Intermediate 46) (265 mg, 0.617 mmol) and 4 M HCl in dioxane (2.00 ml) in EtOAc (2 ml) to afford 202 mg (89%) as a white solid.

Workup

  1. customto afford 202 mg (89%) as a white solid

Sources & evidence

ORD record
ord-e75482eb400147c2b5b214c6089b7ccf
Source dataset
uspto-grants-2009_02
Patent number
US07485636B2

Reaction notes

Loading…