反应详情

65.9 mg of L-tartaric acid was added to 136.68 mg of 1-(2-fluorophenyl)-3-(piperidin-4-yloxy)-1H-indazole (clear oil) in 12.45 ml of methanol. The mixture was place under a stream of N2 gas until only approximately 1 ml of solution remained. Precipitation of the salt was observed during this step. Approximately 5 ml of acetone was added and the subsequent solution was then stirred briefly (˜2 min). A white solid was recovered using vacuum filtration with a membrane filter. The solid was dried in a vacuum dessicator at ambient temperature (pressure not controlled).

1. customPrecipitation of the salt
2. additionApproximately 5 ml of acetone was added
3. customA white solid was recovered
4. filtrationvacuum filtration with a membrane
5. filtrationfilter
6. customThe solid was dried in a vacuum dessicator at ambient temperature (pressure not