反应详情

In a 25 mL flask was placed 1-butyl-piperazine (712 mg, 5.0 mmol), 4-bromobutyronitrile (779 mg, 5.3 mmol) and potassium carbonate (687 mg, 5.0 mmol) suspended in acetonitrile (5 mL). The reaction mixture was stirred at rt for 12 h., followed by addition of H2O (20 mL) and extraction with ethyl acetate (3×25 mL). The combined organic phases were washed with brine (25 mL), dried (MgSO4) and evaporated to dryness to produce 0.89 g of crude 16 which was used without further purification in the synthesis of compound 17.

1. customIn a 25 mL flask was placed
2. washThe combined organic phases were washed with brine (25 mL)
3. dry with materialdried (MgSO4)
4. customevaporated to dryness
5. customto produce 0.89 g of crude 16 which
6. customwas used without further purification in the synthesis of compound 17