Diethylamine → 2-methoxyethyldiethylamine

HRID 1724611Notes

Reaction equation

HRID 1724611 reaction equation
[CH3:1][O:2][CH2:3][CH2:4]Cl.[CH2:6]([NH:8][CH2:9][CH3:10])[CH3:7]>>[CH3:1][O:2][CH2:3][CH2:4][N:8]([CH2:9][CH3:10])[CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 123162-Chloroethyl methyl ether

Product 1

HCID 113555002-methoxyethyldiethylamine

Procedure

A mixed solution prepared by mixing 200 mL of diethylamine (Kanto Chemical Co., Ltd.) and 85 mL of 2-methoxyethyl chloride (produced by Kanto Chemical) was placed in an autoclave and reacted at 120° C. for 50 hours. The internal pressure at this time was 353 kPa (3.6 kgf/cm2). After 10 hours, the crystals that settled out were removed by filtration, and the filtrate was subjected to normal-pressure distillation, yielding 66 g of 2-methoxyethyldiethylamine.

Workup

  1. customA mixed solution prepared
  2. customreacted at 120° C. for 50 hours
  3. customthe crystals that settled out were removed by filtration
  4. distillationthe filtrate was subjected to normal-pressure distillation

Sources & evidence

ORD record
ord-7cf087d509ab46169ea93908372f5724
Source dataset
uspto-grants-2009_02
Patent number
US07488425B2

Reaction notes

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