反应详情

To a solution of (2R,3R,4R,5R)-4-acetyloxy-5-(acetyloxymethyl)-2-(6-chloro-2-iodopurin-9-yl)oxolan-3-yl acetate (1.15 g, 2.13 mmol) in N,N-dimethylformamide (20 ml) was added cyclopentylamine (0.42 ml, 4.26 mmol) and diisopropylethylamine (10 ml), and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and the residue chromatographed on a silica gel column, eluting with a mixture of 40% ethanol/60% hexane, to provide (2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-[6-(cyclopentylamino)-2-iodopurin-9-yl]oxolan-3-yl acetate (0.9 g), a compound of formula (4).

1. customThe solvent was removed under reduced pressure
2. customthe residue chromatographed on a silica gel column
3. washeluting with a mixture of 40% ethanol/60% hexane